3QS5A

Crystal structure of leut mutant i359q bound to sodium and l-tryptophan
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 201
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-261 223 262-511 1-21 22-38 21 249 slipknot
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41 13-293 281 1-12 349-511 294-348 12 163 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAQMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGT
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-287 277 1-10 300-509 288-299 10 210 slipknot
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4.1 8-301 294 1-7 308-509 302-307 7 202 slipknot
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4.1 8-309 302 1-7 316-509 310-315 7 194 slipknot
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3.2 6-315 310 1-5 322-509 316-321 5 188 slipknot
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4.1 7-326 320 1-6 332-509 327-331 6 178 slipknot
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3.2 18-334 317 1-17 349-509 335-348 17 161 slipknot
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2.1 29-259 231 1-15, 273-509 16-28, 260-272 15 237 slipknot
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2.1 24-360 337 1-16, 384-509 17-23, 361-383 16 126 slipknot
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2.1 41-406 366 407-509 1-17 18-40 17 102 slipknot
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2.1 41-351 311 1-18, 386-509 19-40, 352-385 18 124 slipknot
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2.1 28-277 250 1-22, 284-509 23-27, 278-283 22 226 slipknot
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1.1 39-243 205 1-25, 256-509 26-38, 244-255 25 254 slipknot
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1.1 35-280 246 1-26, 292-509 27-34, 281-291 26 218 slipknot
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2.1 40-394 355 1-30, 403-509 31-39, 395-402 30 107 slipknot
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1.1 41-278 238 1-32, 293-509 33-40, 279-292 32 217 slipknot
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3.1 41-260 220 1-33, 273-509 34-40, 261-272 33 237 slipknot
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2.1 41-272 232 1-33, 276-509 34-40, 273-275 33 234 slipknot
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2.1 42-266 225 1-40, 276-509 41-41, 267-275 40 234 slipknot
sequence length 511
structure length 509
publication title Insights into transport mechanism from LeuT engineered to transport tryptophan.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Na(+):neurotransmitter symporter (Snf family)
source organism Aquifex aeolicus
missing residues 129-130
total genus Genus: 201
ec nomenclature
pdb deposition date 2011-02-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling