3QS6A

Crystal structure of leut mutant f259v,i359q bound to sodium and l-tryptophan
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 203
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 38-264 227 265-511 1-24 25-37 24 246 slipknot
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41 13-296 284 1-12 351-511 297-350 12 161 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGVGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAQMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGT
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 9-287 279 1-8 302-509 288-301 8 208 slipknot
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4.1 10-299 290 1-9 308-509 300-307 9 202 slipknot
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3.2 10-307 298 1-9 310-509 308-309 9 200 slipknot
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3.2 14-334 321 1-13 349-509 335-348 13 161 slipknot
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3.2 14-314 301 1-6, 323-509 7-13, 315-322 6 187 slipknot
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4.1 13-299 287 1-9, 307-509 10-12, 300-306 9 203 slipknot
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2.1 43-406 364 407-509 1-15 16-42 15 102 slipknot
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2.1 43-353 311 1-18, 403-509 19-42, 354-402 18 107 slipknot
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2.1 32-260 229 1-19, 271-509 20-31, 261-270 19 239 slipknot
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2.1 26-275 250 1-20, 286-509 21-25, 276-285 20 224 slipknot
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1.1 34-278 245 1-23, 291-509 24-33, 279-290 23 219 slipknot
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2.1 34-290 257 1-25, 292-509 26-33, 291-291 25 218 slipknot
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1.1 40-242 203 1-25, 252-509 26-39, 243-251 25 258 slipknot
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2.1 41-260 220 1-33, 272-509 34-40, 261-271 33 238 slipknot
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1.1 41-275 235 1-33, 288-509 34-40, 276-287 33 222 slipknot
sequence length 511
structure length 509
publication title Insights into transport mechanism from LeuT engineered to transport tryptophan.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Na(+):neurotransmitter symporter (Snf family)
source organism Aquifex aeolicus
missing residues 129-130
total genus Genus: 203
ec nomenclature
pdb deposition date 2011-02-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling