3WBHA

Structural characteristics of alkaline phosphatase from a moderately halophilic bacteria halomonas sp.593
Warning
  • Chain breaks within knotoid 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 186
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-313 304 1-9 465-497 314-464 9 33 slipknot
Chain Sequence
EVKNVILMIGDGMGPQQVGLLETYANQAPDSIYDGEPTAFHQLAKEGVVGFSLTHPEDAVVVDSACSATQLASGIYSGSEVIGIDAEGNPVETVLELAQARGKATGLVSDTRLTHATPAAFAAHQPHRSLENEIAVDMLEVGPDVMLSGGLRHWVPQSASEDAEVTSLMDGAYEPASKRQDDRNLLAEAVEKGYGLAFSREQLEADQSDKLLGLFANSGMADGIEYRNTRDDADRREPTLHEMTQAALNRLEQDEDGFFLMVEGGQIDWAGHSNDAGTMLNEMVKFEEAVQGVYDWAKGREDTVILVTADHETGAFGLSYSSADLPEPQSKSGPAFAERDYAPNFNFGDFALLDSLYHQKASFSTLLSEFGALEEEQRTPARLMEMVNANSDFQIDEEQAEAVLADKPNPYHVEGHSYLEAEEVPAIQDFDAFYPYNDRGNVLGRVLGTAQNVVWGTGTHTHTPVNVFAWGPAETILPVSSIQHHSEVGQYLKSLVE
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 12x -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 13-116 104 1-12, 117-147 12 31 knot
Fingerprint Knot forming loop Loop type
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Ala45 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Lys46 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Ala45 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> Asp269 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Lys46 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Ala45 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... Asp311 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Lys46 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Ala45 ... Glu2		 probabilistic
K -31
Chain closureGlu2 <-> Glu498
... His461 <->
Bridging ionZn504
<-> His273 ... His312 <->
Bridging ionZn505
<-> Ser65 ... Gly48 <->
Bridging ionMg502
<-> Lys46 ... Glu2		 probabilistic
Chain Sequence
EVKNVILMIGDGMGPQQVGLLETYANQAPDSIYDGEPTAFHQLAKEGVVGFSLTHPEDAVVVDSACSATQLASGIYSGSEVIGIDAEGNPVETVLELAQARGKATGLVSDTRLTHATPAAFAAHQPHRSLENEIAVDMLEVGPDVMLSGGLRHWVPQSASEDAEVTSLMDGAYEPASKRQDDRNLLAEAVEKGYGLAFSREQLEADQSDKLLGLFANSGMADGIEYRNTRDDADRREPTLHEMTQAALNRLEQDEDGFFLMVEGGQIDWAGHSNDAGTMLNEMVKFEEAVQGVYDWAKGREDTVILVTADHETGAFGLSYSSADLPEPQSKSGPAFAERDYAPNFNFGDFALLDSLYHQKASFSTLLSEFGALEEEQRTPARLMEMVNANSDFQIDEEQAEAVLADKPNPYHVEGHSYLEAEEVPAIQDFDAFYPYNDRGNVLGRVLGTAQNVVWGTGTHTHTPVNVFAWGPAETILPVSSIQHHSEVGQYLKSLVE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 9-313 305 1-8 464-497 314-463 8 34 slipknot
sequence length 497
structure length 497
publication title Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593.
doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Halomonas
total genus Genus: 186
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2013-05-17
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling