4FXZA

Crystal structure of leut-f253a bound to l-leucine from lipid bicelles
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 209
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-260 222 261-505 1-21 22-38 21 244 slipknot
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41 14-294 281 1-13 359-505 295-358 13 147 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFATLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRN
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 10-288 279 1-9 301-502 289-300 9 202 slipknot
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3.2 8-300 293 1-7 304-502 301-303 7 199 slipknot
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4.1 8-303 296 1-7 305-502 304-304 7 198 slipknot
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4.1 11-305 295 1-10 312-502 306-311 10 191 slipknot
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4.1 9-326 318 1-8 334-502 327-333 8 169 slipknot
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3.2 17-333 317 1-16 348-502 334-347 16 155 slipknot
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4.1 11-297 287 1-7, 304-502 8-10, 298-303 7 199 slipknot
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4.1 11-303 293 1-8, 305-502 9-10, 304-304 8 198 slipknot
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2.1 32-252 221 1-15, 269-502 16-31, 253-268 15 234 slipknot
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1.1 25-274 250 1-16, 285-502 17-24, 275-284 16 218 slipknot
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2.1 31-431 401 1-17, 455-502 18-30, 432-454 17 48 slipknot
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2.1 25-484 460 1-17, 499-502 18-24, 485-498 17 4 slipknot
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2.1 42-407 366 408-502 1-18 19-41 18 94 slipknot
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2.1 43-354 312 1-19, 398-502 20-42, 355-397 19 105 slipknot
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1.1 27-246 220 1-21, 253-502 22-26, 247-252 21 250 slipknot
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1.1 31-242 212 1-22, 253-502 23-30, 243-252 22 250 slipknot
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1.1 32-243 212 1-30, 253-502 31-31, 244-252 30 250 slipknot
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1.1 39-276 238 1-25, 293-502 26-38, 277-292 25 210 slipknot
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2.1 39-292 254 1-25, 294-502 26-38, 293-293 25 209 slipknot
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1.1 39-242 204 1-31, 254-502 32-38, 243-253 31 249 slipknot
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1.1 38-253 216 1-31, 257-502 32-37, 254-256 31 246 slipknot
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2.1 42-257 216 1-34, 275-502 35-41, 258-274 34 228 slipknot
sequence length 505
structure length 502
publication title Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130
total genus Genus: 209
ec nomenclature
pdb deposition date 2012-07-03
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling