4HPVA

Crystal structure of s-adenosylmethionine synthetase from sulfolobus solfataricus
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-291 266 1-25, 292-404 25 113 knot
Chain Sequence
MRNINVQLNPLSDIEKLQVELVERKGLGHPDYIADAVAEEASRKLSLYYLKKYGVILHHNLDKTLVVGGQATPRFKGGDIIQPIYIIVAGRATTEVKTESGIDQIPVGTIIIESVKEWIRNNFRYLDAERHVIVDYKIGKGSSDLV------KRVPLSNDTSFGVGFAPLTKLEKLVYETERHLNSKQFKAKLPEVGEDIKVMGLRRGNEVDLTIAMATISELIEDVNHYINVKEQVRNQILDLASKIAPGYNVRVYVNTGDKIDKNILYLTVTGTSAEHGDDGMTGRGNRGVGLITPMRPMSLEATAGKNPVNHVGKLYNVLANLIANKIAQEVKDVKFSQVQVLGQIGRPIDDPLIANVDVITYDGKLTDETKNEISGIVDEMLSSFNKLTELILEGKATLF
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 21-389 369 1-20, 390-398 20 9 knot
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3.1 24-315 292 1-23 384-398 316-383 23 15 slipknot
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3.1 24-383 360 1-23 390-398 384-389 23 9 slipknot
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2.1 22-389 368 1-20, 396-398 21-21, 390-395 20 3 slipknot
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2.1 35-316 282 1-23, 384-398 24-34, 317-383 23 15 slipknot
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2.1 34-383 350 1-23, 387-398 24-33, 384-386 23 12 slipknot
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2.1 32-386 355 1-22, 391-398 23-31, 387-390 22 8 slipknot
sequence length 404
structure length 398
publication title Understanding Molecular Recognition of Promiscuity of Thermophilic Methionine Adenosyltransferase, sMAT from Sulfolobus solfataricus.
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-adenosylmethionine synthase
source organism Sulfolobus solfataricus
missing residues 147-152
total genus Genus: 140
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2012-10-24
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01941 AdoMet_Synthase S-adenosylmethionine synthetase (AdoMet synthetase)
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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