4HPVA

Crystal structure of s-adenosylmethionine synthetase from sulfolobus solfataricus
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-291 266 1-25, 292-404 25 113 knot
Chain Sequence
MRNINVQLNPLSDIEKLQVELVERKGLGHPDYIADAVAEEASRKLSLYYLKKYGVILHHNLDKTLVVGGQATPRFKGGDIIQPIYIIVAGRATTEVKTESGIDQIPVGTIIIESVKEWIRNNFRYLDAERHVIVDYKIGKGSSDLV------KRVPLSNDTSFGVGFAPLTKLEKLVYETERHLNSKQFKAKLPEVGEDIKVMGLRRGNEVDLTIAMATISELIEDVNHYINVKEQVRNQILDLASKIAPGYNVRVYVNTGDKIDKNILYLTVTGTSAEHGDDGMTGRGNRGVGLITPMRPMSLEATAGKNPVNHVGKLYNVLANLIANKIAQEVKDVKFSQVQVLGQIGRPIDDPLIANVDVITYDGKLTDETKNEISGIVDEMLSSFNKLTELILEGKATLF
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 21-389 369 1-20, 390-398 20 9 knot
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3.1 24-315 292 1-23 384-398 316-383 23 15 slipknot
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3.1 24-383 360 1-23 390-398 384-389 23 9 slipknot
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2.1 22-389 368 1-20, 396-398 21-21, 390-395 20 3 slipknot
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2.1 35-316 282 1-23, 384-398 24-34, 317-383 23 15 slipknot
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2.1 34-383 350 1-23, 387-398 24-33, 384-386 23 12 slipknot
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2.1 32-386 355 1-22, 391-398 23-31, 387-390 22 8 slipknot
missing residues 147-152
publication title Understanding Molecular Recognition of Promiscuity of Thermophilic Methionine Adenosyltransferase, sMAT from Sulfolobus solfataricus.
pubmed doi rcsb
structure length 398
molecule tags Transferase
source organism Sulfolobus solfataricus
sequence length 404
total genus Genus: 140
molecule keywords S-adenosylmethionine synthase
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2012-10-24
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01941 AdoMet_Synthase S-adenosylmethionine synthetase (AdoMet synthetase)
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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