4KM4A

E. coli alkaline phosphatase mutant s102g/r166s in complex with inorganic phosphate
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 45-366 322 1-44 416-445 367-415 44 30 slipknot
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDGAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 45-368 324 1-44 413-445 369-412 44 33 slipknot
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3.1 41-412 372 1-40 417-445 413-416 40 29 slipknot
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2.1 41-416 376 1-2, 418-445 3-40, 417-417 2 28 slipknot
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3.1 42-412 371 1-40, 416-445 41-41, 413-415 40 30 slipknot
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3.1 16-364 349 1-9, 369-445 10-15, 365-368 9 77 slipknot
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2.1 33-363 331 1-12, 369-445 13-32, 364-368 12 77 slipknot
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2.1 35-363 329 1-32, 369-445 33-34, 364-368 32 77 slipknot
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2.1 36-363 328 1-34, 369-445 35-35, 364-368 34 77 slipknot
sequence length 445
structure length 445
publication title Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
total genus Genus: 167
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2013-05-08
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
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