4MM6A

Crystal structure of leubat (delta13 mutant) in complex with (s)-duloxetine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-263 227 264-507 1-21 22-36 21 243 slipknot
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41 13-294 282 1-12 346-507 295-345 12 162 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVASYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWATGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 14-286 273 1-13 300-504 287-299 13 205 slipknot
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4.1 12-299 288 1-11 309-504 300-308 11 196 slipknot
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4.1 9-325 317 1-8 331-504 326-330 8 174 slipknot
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3.2 15-330 316 1-14 348-504 331-347 14 157 slipknot
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4.1 10-312 303 1-2, 319-504 3-9, 313-318 2 186 slipknot
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1.1 27-254 228 1-15, 271-504 16-26, 255-270 15 234 slipknot
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2.1 41-417 377 418-504 1-16 17-40 16 86 slipknot
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1.1 25-274 250 1-17, 285-504 18-24, 275-284 17 220 slipknot
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2.1 41-402 362 1-17, 417-504 18-40, 403-416 17 88 slipknot
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2.1 40-351 312 1-19, 398-504 20-39, 352-397 19 107 slipknot
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1.1 35-242 208 1-22, 256-504 23-34, 243-255 22 249 slipknot
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1.1 33-276 244 1-25, 290-504 26-32, 277-289 25 215 slipknot
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1.1 40-274 235 1-27, 294-504 28-39, 275-293 27 211 slipknot
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2.1 40-259 220 1-30, 267-504 31-39, 260-266 30 238 slipknot
missing residues 128-130
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
structure length 504
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 507
total genus Genus: 209
molecule keywords Transporter
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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