4MM7A

Crystal structure of leubat (delta13 mutant) in complex with desvenlafaxine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-264 228 265-507 1-20 21-36 20 242 slipknot
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41 13-294 282 1-12 349-507 295-348 12 159 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVASYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWATGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPTHW-----TVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 10-286 277 1-9 300-499 287-299 9 200 slipknot
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4.1 12-299 288 1-11 307-499 300-306 11 193 slipknot
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4.1 6-310 305 1-5 321-499 311-320 5 179 slipknot
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4.1 17-331 315 1-16 345-499 332-344 16 155 slipknot
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3.2 15-325 311 1-8, 330-499 9-14, 326-329 8 170 slipknot
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3.2 13-329 317 1-8, 331-499 9-12, 330-330 8 169 slipknot
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1.1 20-277 258 1-15, 285-499 16-19, 278-284 15 215 slipknot
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1.1 25-275 251 1-16, 288-499 17-24, 276-287 16 212 slipknot
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1.1 40-259 220 1-17, 273-499 18-39, 260-272 17 227 slipknot
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2.1 40-352 313 1-18, 398-499 19-39, 353-397 18 102 slipknot
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1.1 37-241 205 1-23, 259-499 24-36, 242-258 23 241 slipknot
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1.1 41-273 233 1-25, 293-499 26-40, 274-292 25 207 slipknot
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2.1 37-398 362 1-30, 405-499 31-36, 399-404 30 95 slipknot
missing residues 128-130, 470-474
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
structure length 499
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 507
total genus Genus: 204
molecule keywords Transporter
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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