4MM8A

Crystal structure of leubat (delta13 mutant) in complex with (r)-fluoxetine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 202
Slipknot S +31 41 +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 37-264 228 265-507 1-21 22-36 21 242 slipknot
view details
41 13-294 282 1-12 346-507 295-345 12 162 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVASYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWATGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYITHW------TVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.2 11-286 276 1-10 299-498 287-298 10 200 slipknot
view details
2.3 11-300 290 1-10 309-498 301-308 10 190 slipknot
view details
3.2 5-311 307 1-4 319-498 312-318 4 180 slipknot
view details
3.2m 17-324 308 1-16 345-498 325-344 16 154 slipknot
view details
1.1 22-274 253 1-15, 284-498 16-21, 275-283 15 215 slipknot
view details
2.1 25-355 331 1-16, 378-498 17-24, 356-377 16 121 slipknot
view details
2.1 41-409 369 410-498 1-17 18-40 17 88 slipknot
view details
2.1 40-254 215 1-18, 272-498 19-39, 255-271 18 227 slipknot
view details
2.1 41-352 312 1-18, 397-498 19-40, 353-396 18 102 slipknot
view details
1.1 38-241 204 1-22, 251-498 23-37, 242-250 22 248 slipknot
view details
1.1 38-250 213 1-22, 255-498 23-37, 251-254 22 244 slipknot
view details
1.1 39-243 205 1-37, 248-498 38-38, 244-247 37 251 slipknot
view details
1.1 41-274 234 1-24, 292-498 25-40, 275-291 24 207 slipknot
view details
1.1 41-291 251 1-24, 295-498 25-40, 292-294 24 204 slipknot
view details
1.1 40-271 232 1-25, 275-498 26-39, 272-274 25 224 slipknot
view details
3.1 41-272 232 1-39, 275-498 40-40, 273-274 39 224 slipknot
sequence length 507
structure length 498
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130, 469-474
total genus Genus: 202
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling