4MM9A

Crystal structure of leubat (delta13 mutant) in complex with fluvoxamine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-264 228 265-507 1-21 22-36 21 242 slipknot
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41 13-297 285 1-12 349-507 298-348 12 159 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVASYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWATGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKHWT-----VWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-286 276 1-10 300-499 287-299 10 200 slipknot
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4.1 10-299 290 1-9 307-499 300-306 9 193 slipknot
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4.1 10-306 297 1-9 312-499 307-311 9 188 slipknot
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3.2 8-311 304 1-7 315-499 312-314 7 185 slipknot
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3.2 17-331 315 1-16 347-499 332-346 16 153 slipknot
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3.2 11-300 290 1-9, 311-499 10-10, 301-310 9 189 slipknot
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2.1 41-411 371 412-499 1-16 17-40 16 87 slipknot
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2.1 40-397 358 1-17, 412-499 18-39, 398-411 17 88 slipknot
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1.1 33-255 223 1-18, 264-499 19-32, 256-263 18 236 slipknot
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2.1 33-263 231 1-18, 272-499 19-32, 264-271 18 228 slipknot
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2.1 33-271 239 1-18, 273-499 19-32, 272-272 18 227 slipknot
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2.1 41-351 311 1-19, 366-499 20-40, 352-365 19 134 slipknot
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1.1 29-243 215 1-22, 256-499 23-28, 244-255 22 244 slipknot
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1.1 38-242 205 1-24, 257-499 25-37, 243-256 24 243 slipknot
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1.1 41-276 236 1-25, 291-499 26-40, 277-290 25 209 slipknot
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1.1 40-290 251 1-26, 292-499 27-39, 291-291 26 208 slipknot
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1.1 41-274 234 1-26, 277-499 27-40, 275-276 26 223 slipknot
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1.1 38-269 232 1-28, 275-499 29-37, 270-274 28 225 slipknot
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2.1 40-261 222 1-33, 270-499 34-39, 262-269 33 230 slipknot
missing residues 128-130, 471-475
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
structure length 499
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 507
total genus Genus: 206
molecule keywords Transporter
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling