4MMBA

Crystal structure of leubat (delta6 mutant) in complex with sertraline
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 211
Slipknot S +31 41 +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 37-264 228 265-507 1-21 22-36 21 242 slipknot
view details
41 13-293 281 1-12 349-507 294-348 12 159 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGAIITFASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.2 11-286 276 1-10 300-504 287-299 10 205 slipknot
view details
4.1 12-299 288 1-11 307-504 300-306 11 198 slipknot
view details
3.2 7-307 301 1-6 317-504 308-316 6 188 slipknot
view details
4.1 10-318 309 1-9 325-504 319-324 9 180 slipknot
view details
4.1 7-326 320 1-6 333-504 327-332 6 172 slipknot
view details
3.2 13-332 320 1-12 348-504 333-347 12 157 slipknot
view details
3.2 15-313 299 1-7, 319-504 8-14, 314-318 7 186 slipknot
view details
2.1 40-350 311 1-16, 391-504 17-39, 351-390 16 114 slipknot
view details
2.1 41-401 361 402-504 1-16 17-40 16 102 slipknot
view details
1.1 32-254 223 1-17, 268-504 18-31, 255-267 17 237 slipknot
view details
1.1 25-272 248 1-17, 287-504 18-24, 273-286 17 218 slipknot
view details
1.1 32-242 211 1-19, 255-504 20-31, 243-254 19 250 slipknot
view details
1.1 28-273 246 1-24, 280-504 25-27, 274-279 24 225 slipknot
view details
1.1 33-242 210 1-31, 257-504 32-32, 243-256 31 248 slipknot
view details
1.1 41-272 232 1-26, 285-504 27-40, 273-284 26 220 slipknot
view details
1.1 41-284 244 1-26, 288-504 27-40, 285-287 26 217 slipknot
view details
1.1 36-242 207 1-32, 257-504 33-35, 243-256 32 248 slipknot
view details
2.1 36-256 221 1-31, 260-504 32-35, 257-259 31 245 slipknot
view details
1.1 37-249 213 1-35, 260-504 36-36, 250-259 35 245 slipknot
view details
2.1 40-259 220 1-33, 267-504 34-39, 260-266 33 238 slipknot
sequence length 507
structure length 504
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130
total genus Genus: 211
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling