4MMCA

Crystal structure of leubat (delta6 mutant) in complex with desvenlafaxine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 211
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-264 228 265-507 1-21 22-36 21 242 slipknot
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41 13-297 285 1-12 346-507 298-345 12 162 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGAIITFASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-288 278 1-10 300-504 289-299 10 205 slipknot
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4.1 10-299 290 1-9 310-504 300-309 9 195 slipknot
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4.1 6-309 304 1-5 313-504 310-312 5 192 slipknot
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4.1 8-326 319 1-7 334-504 327-333 7 171 slipknot
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3.2m 17-329 313 1-16 348-504 330-347 16 157 slipknot
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2.1 21-360 340 1-15, 372-504 16-20, 361-371 15 133 slipknot
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1.1 24-272 249 1-17, 280-504 18-23, 273-279 17 225 slipknot
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2.1 39-355 317 1-17, 398-504 18-38, 356-397 17 107 slipknot
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2.1 34-254 221 1-18, 268-504 19-33, 255-267 18 237 slipknot
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2.1 41-440 400 441-504 1-18 19-40 18 63 slipknot
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1.1 37-242 206 1-21, 254-504 22-36, 243-253 21 251 slipknot
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1.1 40-276 237 1-23, 293-504 24-39, 277-292 23 212 slipknot
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2.1 40-403 364 1-24, 420-504 25-39, 404-419 24 85 slipknot
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1.1 35-253 219 1-25, 257-504 26-34, 254-256 25 248 slipknot
sequence length 507
structure length 504
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130
total genus Genus: 211
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling