4MMEA

Crystal structure of leubat (delta6 mutant) in complex with mazindol
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 214
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-263 227 264-507 1-20 21-36 20 243 slipknot
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41 13-293 281 1-12 346-507 294-345 12 162 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGAIITFASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 12-286 275 1-11 299-504 287-298 11 206 slipknot
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4.1 10-298 289 1-9 312-504 299-311 9 193 slipknot
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4.1 7-311 305 1-6 317-504 312-316 6 188 slipknot
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3.2 18-331 314 1-17 345-504 332-344 17 160 slipknot
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2.1 33-408 376 1-16, 478-504 17-32, 409-477 16 27 slipknot
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4.10m 24-481 458 1-16, 492-504 17-23, 482-491 16 13 slipknot
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1.1 32-260 229 1-17, 276-504 18-31, 261-275 17 229 slipknot
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2.1 38-354 317 1-17, 398-504 18-37, 355-397 17 107 slipknot
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2.1 41-405 365 406-504 1-18 19-40 18 98 slipknot
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2.1 32-252 221 1-19, 259-504 20-31, 253-258 19 246 slipknot
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1.1 29-251 223 1-22, 253-504 23-28, 252-252 22 252 slipknot
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1.1 37-242 206 1-24, 253-504 25-36, 243-252 24 252 slipknot
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1.1 37-252 216 1-31, 254-504 32-36, 253-253 31 251 slipknot
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1.1 37-253 217 1-31, 257-504 32-36, 254-256 31 248 slipknot
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1.1 32-281 250 1-25, 292-504 26-31, 282-291 25 213 slipknot
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2.1 41-272 232 1-26, 281-504 27-40, 273-280 26 224 slipknot
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1.1 41-280 240 1-26, 291-504 27-40, 281-290 26 214 slipknot
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2.1 40-260 221 1-33, 273-504 34-39, 261-272 33 232 slipknot
sequence length 507
structure length 504
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130
total genus Genus: 214
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling