4MMFA

Crystal structure of leubat (delta5 mutant) in complex with mazindol
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 213
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 36-263 228 264-507 1-19 20-35 19 243 slipknot
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41 13-293 281 1-12 347-507 294-346 12 161 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 14-287 274 1-13 299-504 288-298 13 206 slipknot
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4.1 7-299 293 1-6 307-504 300-306 6 198 slipknot
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4.1 6-307 302 1-5 312-504 308-311 5 193 slipknot
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4.1 7-317 311 1-6 322-504 318-321 6 183 slipknot
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3.2 12-332 321 1-11 348-504 333-347 11 157 slipknot
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4.1 10-323 314 1-3, 328-504 4-9, 324-327 3 177 slipknot
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4.1 11-328 318 1-3, 333-504 4-10, 329-332 3 172 slipknot
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4.1 12-298 287 1-7, 305-504 8-11, 299-304 7 200 slipknot
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3.2 16-330 315 1-11, 337-504 12-15, 331-336 11 168 slipknot
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2.1 21-367 347 1-15, 379-504 16-20, 368-378 15 126 slipknot
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2.1 20-488 469 1-15, 501-504 16-19, 489-500 15 4 slipknot
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2.1 40-351 312 1-16, 391-504 17-39, 352-390 16 114 slipknot
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2.1 34-255 222 1-19, 267-504 20-33, 256-266 19 238 slipknot
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2.1 38-245 208 1-20, 258-504 21-37, 246-257 20 247 slipknot
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1.1 39-270 232 1-20, 289-504 21-38, 271-288 20 216 slipknot
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2.1 40-393 354 1-31, 405-504 32-39, 394-404 31 100 slipknot
sequence length 507
structure length 504
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130
total genus Genus: 213
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling