4O6BA

Dengue type2 virus non-structural protein 1 (ns1) form 1 crystal
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 71
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 58-150 93 151-350 1-48 49-57 48 199 slipknot
Chain Sequence
ADSGCVVS---KELKCGSGIFITDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQHNQ---------------------TFLIDGPETAECPNTNRAWNSLEVEDYNIWLKLKEKQDVFCDSKLMSAAIK-------DNRAVHADMGYWIESALNDTWKIEKASFIEVKNCHWPKSHTLWSNGVLESEMIIPKNLAGPVSQHNYRPGYHTQITGPWHLGKLEMDFDFCDGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSL
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 55-126 72 127-319 1-43 44-54 43 192 slipknot
sequence length 350
structure length 319
publication title Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
pubmed doi rcsb
molecule tags Viral protein
molecule keywords Non-structural protein 1
source organism Dengue virus 2
missing residues 9-11, 109-129, 160-166
total genus Genus: 71
ec nomenclature ec 2.1.1.56: mRNA (guanine-N(7)-)-methyltransferase.
ec 2.1.1.57: Methyltransferase cap1.
ec 2.7.7.48: RNA-directed RNA polymerase.
ec 3.4.21.91: Flavivirin.
ec 3.6.1.15: Nucleoside-triphosphate phosphatase.
ec 3.6.4.13: RNA helicase.
pdb deposition date 2013-12-20
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00948 Flavi_NS1 Flavivirus non-structural Protein NS1
Image from the rcsb pdb (www.rcsb.org)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling