4O6BA

Dengue type2 virus non-structural protein 1 (ns1) form 1 crystal
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 58-150 93 151-350 1-48 49-57 48 199 slipknot
Chain Sequence
ADSGCVVS---KELKCGSGIFITDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQHNQ---------------------TFLIDGPETAECPNTNRAWNSLEVEDYNIWLKLKEKQDVFCDSKLMSAAIK-------DNRAVHADMGYWIESALNDTWKIEKASFIEVKNCHWPKSHTLWSNGVLESEMIIPKNLAGPVSQHNYRPGYHTQITGPWHLGKLEMDFDFCDGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 55-126 72 127-319 1-43 44-54 43 192 slipknot
missing residues 9-11, 109-129, 160-166
publication title Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
pubmed doi rcsb
structure length 319
molecule tags Viral protein
source organism Dengue virus 2
sequence length 350
total genus Genus: 71
molecule keywords Non-structural protein 1
ec nomenclature ec 2.1.1.56: mRNA (guanine-N(7)-)-methyltransferase.
ec 2.1.1.57: Methyltransferase cap1.
ec 2.7.7.48: RNA-directed RNA polymerase.
ec 3.4.21.91: Flavivirin.
ec 3.6.1.15: Nucleoside-triphosphate phosphatase.
ec 3.6.4.13: RNA helicase.
pdb deposition date 2013-12-20
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00948 Flavi_NS1 Flavivirus non-structural Protein NS1
Image from the rcsb pdb (www.rcsb.org)
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling