4OQXA

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with me-ara-edu
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 114
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 6-118 113 1-5 307-330 119-306 5 24 slipknot
Chain Sequence
KMPTLLRVYIDGPHGMGKTTTTQLLVA--SRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAPP-----PALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPHIGD---------------TLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-113 106 1-7 149-308 114-148 7 160 slipknot
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3.1 9-149 141 1-8 258-308 150-257 8 51 slipknot
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3.1 5-257 253 1-4 282-308 258-281 4 27 slipknot
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3.1 5-281 277 1-4 283-308 282-282 4 26 slipknot
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2.1 10-258 249 1-4, 282-308 5-9, 259-281 4 27 slipknot
sequence length 330
structure length 308
publication title Crystal structure of HSV1-TK complexed with Me-ARA-EdU
rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Human herpesvirus 1
missing residues 28-29, 104-108, 221-235
total genus Genus: 114
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2014-02-10
KnotProt deposition date 2014-08-16
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling