4WLPA

Crystal structure of uch37-nfrkb inhibited deubiquitylating complex
Warning
  • Chain breaks within knot 52 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 102
Alphaknot: Q9Y5K5
Knot K -52 -31 -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-52 8-219 212 1-7, 220-317 7 98 knot
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-31 7-160 154 1-6 218-317 161-217 6 100 slipknot
Chain Sequence
AGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQM---------KEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQSMLSAIQSE------------VAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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5.2m 7-212 206 1-6, 213-296 6 84 knot
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2.1m 9-150 142 1-8 160-296 151-159 8 137 slipknot
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3.1m 7-173 167 1-6 206-296 174-205 6 91 slipknot
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4.4m 10-214 205 1-6, 253-296 7-9, 215-252 6 44 slipknot
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5.2m 10-252 243 1-6, 261-296 7-9, 253-260 6 36 slipknot
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5.2m 10-260 251 261-296 1-6 7-9 6 35 slipknot
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1.1m 11-184 174 1-6, 205-296 7-10, 185-204 6 92 slipknot
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2.1m 10-204 195 1-3, 207-296 4-9, 205-206 3 90 slipknot
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5.2m 10-213 204 1-6, 215-296 7-9, 214-214 6 82 slipknot
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4.4m 12-253 242 1-9, 296-296 10-11, 254-295 9 1 slipknot
sequence length 317
structure length 296
publication title Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.
doi rcsb
molecule tags Protein binding
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
source organism Homo sapiens
missing residues 145-153, 238-249
total genus Genus: 102
ec nomenclature
pdb deposition date 2014-10-07
KnotProt deposition date 2015-03-05
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling