4WLPA

Crystal structure of uch37-nfrkb inhibited deubiquitylating complex
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 52 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K -52 -31 -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 7-160 154 1-6 218-317 161-217 6 100 slipknot
view details
-52 8-219 212 1-7, 220-317 7 98 knot
Chain Sequence
AGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQM---------KEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQSMLSAIQSE------------VAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
5.2m 7-212 206 1-6, 213-296 6 84 knot
view details
2.1m 9-150 142 1-8 160-296 151-159 8 137 slipknot
view details
3.1m 7-173 167 1-6 206-296 174-205 6 91 slipknot
view details
4.4m 10-214 205 1-6, 253-296 7-9, 215-252 6 44 slipknot
view details
5.2m 10-252 243 1-6, 261-296 7-9, 253-260 6 36 slipknot
view details
5.2m 10-260 251 261-296 1-6 7-9 6 35 slipknot
view details
1.1m 11-184 174 1-6, 205-296 7-10, 185-204 6 92 slipknot
view details
2.1m 10-204 195 1-3, 207-296 4-9, 205-206 3 90 slipknot
view details
5.2m 10-213 204 1-6, 215-296 7-9, 214-214 6 82 slipknot
view details
4.4m 12-253 242 1-9, 296-296 10-11, 254-295 9 1 slipknot
missing residues 145-153, 238-249
publication title Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.
doi rcsb
structure length 296
molecule tags Protein binding
source organism Homo sapiens
sequence length 317
total genus Genus: 102
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
ec nomenclature
pdb deposition date 2014-10-07
KnotProt deposition date 2015-03-05
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling