4XDJA

Crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) in an alternate conformation (form 2)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 8x -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 93-239 147 1-92, 240-262 92 23 knot
Fingerprint Knot forming loop Loop type
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Ile173 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
 probabilistic
K -31 Ile173 <->
Bridging ionK601
<-> Gly283 ... Val282 <->
Bridging ionK602
<-> Ile173		 ion-based
K -31 Lys73 ... Gly174 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
 probabilistic
K -31 Ile173 ... Gly174 <->
Bridging ionK601
<-> Gly283 ... Val282 <->
Bridging ionK602
<-> Ile173		 ion-based
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Gly174 <->
Bridging ionK601
<-> Val282 ...
Chain closureLys333 <-> Lys73
 probabilistic
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Val282 ...
Chain closureLys333 <-> Lys73
 probabilistic
K -31 Thr172 <->
Bridging ionK602
<-> Val282 ... Thr281 <->
Bridging ionK602
<-> Thr172		 ion-based
K -31 Thr172 ... Gly174 <->
Bridging ionK601
<-> Gly283 ... Val282 <->
Bridging ionK602
<-> Thr172		 ion-based
Chain Sequence
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGN-----SHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVVSQTK-----IRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKK
sequence length 261
structure length 251
publication title K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords POTASSIUM CHANNEL SUBFAMILY K MEMBER 10
source organism Homo sapiens
missing residues 78-82, 154-158
total genus Genus: 89
ec nomenclature
pdb deposition date 2014-12-19
KnotProt deposition date 2018-10-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07885 Ion_trans_2 Ion channel
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling