4XDLA

Crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) in complex with a brominated fluoxetine derivative.
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 8x -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 96-240 145 1-95, 241-262 95 22 knot
Fingerprint Knot forming loop Loop type
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Ile173 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Gly174 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Ile173 <->
Bridging ionK601
<-> Val282 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Gly174 <->
Bridging ionK601
<-> Val282 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Glu113 <->
Bridging ionCd604
<-> Glu116 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Ile173 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Glu113 <->
Bridging ionCd604
<-> Glu116 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Gly174 <->
Bridging ionK601
<-> Gly283 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Glu113 <->
Bridging ionCd604
<-> Glu116 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Ile173 <->
Bridging ionK601
<-> Val282 ...
Chain closureLys333 <-> Lys73
probabilistic
K -31 Lys73 ... Glu113 <->
Bridging ionCd604
<-> Glu116 ... Thr172 <->
Bridging ionK602
<-> Thr281 ... Gly174 <->
Bridging ionK601
<-> Val282 ...
Chain closureLys333 <-> Lys73
probabilistic
Chain Sequence
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKK
sequence length 261
structure length 261
publication title K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Potassium channel subfamily K member 10
source organism Homo sapiens
total genus Genus: 89
ec nomenclature
pdb deposition date 2014-12-19
KnotProt deposition date 2018-10-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07885 Ion_trans_2 Ion channel
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling