4XNUA

X-ray structure of drosophila dopamine transporter in complex with nisoxetine
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 38-266 229 267-532 1-21 22-37 21 265 slipknot
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41 16-295 280 1-15 353-532 296-352 15 180 slipknot
Chain Sequence
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAALLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWADAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYLLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 13-292 280 1-12 304-532 293-303 12 229 slipknot
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4.1 12-303 292 1-11 318-532 304-317 11 215 slipknot
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4.1 12-317 306 1-11 321-532 318-320 11 212 slipknot
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4.1 18-329 312 1-17 351-532 330-350 17 182 slipknot
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3.2 20-304 285 1-13, 310-532 14-19, 305-309 13 223 slipknot
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2.1 28-265 238 1-17, 278-532 18-27, 266-277 17 255 slipknot
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1.1 23-283 261 1-17, 295-532 18-22, 284-294 17 238 slipknot
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2.1 43-405 363 1-18, 442-532 19-42, 406-441 18 91 slipknot
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2.1 43-441 399 1-18, 501-532 19-42, 442-500 18 32 slipknot
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1.1 35-248 214 1-21, 260-532 22-34, 249-259 21 273 slipknot
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1.1 42-278 237 1-24, 299-532 25-41, 279-298 24 234 slipknot
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2.1 43-263 221 1-28, 279-532 29-42, 264-278 28 254 slipknot
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2.1 43-281 239 1-41, 299-532 42-42, 282-298 41 234 slipknot
publication title X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
pubmed doi rcsb
structure length 532
molecule tags Transport protein/inhibitor
source organism Drosophila melanogaster
sequence length 532
total genus Genus: 214
molecule keywords Integral membrane protein-dopamine transporter
ec nomenclature
pdb deposition date 2015-01-16
KnotProt deposition date 2015-11-11
Image from the rcsb pdb (www.rcsb.org)
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