4XPFA

X-ray structure of drosophila dopamine transporter with subsiteb mutations (d121g/s426m) bound to rti-55
Slipknot S +31 41
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 38-266 229 267-532 1-21 22-37 21 265 slipknot
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41 15-294 280 1-14 353-532 295-352 14 180 slipknot
Chain Sequence
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 12-291 280 1-11 304-532 292-303 11 229 slipknot
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4.1 13-303 291 1-12 322-532 304-321 12 211 slipknot
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3.2 20-336 317 1-19 351-532 337-350 19 182 slipknot
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4.1 13-321 309 1-4, 326-532 5-12, 322-325 4 207 slipknot
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4.1 10-328 319 1-5, 334-532 6-9, 329-333 5 199 slipknot
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4.1 18-304 287 1-12, 310-532 13-17, 305-309 12 223 slipknot
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3.2 19-328 310 1-14, 334-532 15-18, 329-333 14 199 slipknot
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2.1 43-420 378 421-532 1-16 17-42 16 111 slipknot
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2.1 43-359 317 1-17, 395-532 18-42, 360-394 17 138 slipknot
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2.1 33-262 230 1-20, 273-532 21-32, 263-272 20 260 slipknot
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1.1 39-248 210 1-23, 264-532 24-38, 249-263 23 269 slipknot
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1.1 39-263 225 1-32, 265-532 33-38, 264-264 32 268 slipknot
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1.1 40-248 209 1-38, 256-532 39-39, 249-255 38 277 slipknot
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1.1 43-280 238 1-25, 299-532 26-42, 281-298 25 234 slipknot
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2.1 36-402 367 1-30, 408-532 31-35, 403-407 30 125 slipknot
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2.1 40-404 365 1-32, 414-532 33-39, 405-413 32 119 slipknot
publication title Structural basis for neurotransmitter and psycho stimulant recognition by the Drosophila dopamine transporter
rcsb
structure length 532
molecule tags Transport protein/inhibitor
source organism Drosophila melanogaster
sequence length 532
total genus Genus: 188
molecule keywords Dopamine transporter-protein
ec nomenclature
pdb deposition date 2015-01-16
KnotProt deposition date 2015-05-07
Image from the rcsb pdb (www.rcsb.org)
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