4Z0Q | KnotProt

Genus: 73
Alphaknot: P00918

Slipknot S +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	25-257	233	1-24, 258-259			24	2	knot

Chain Sequence

HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK

Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!

Knot K 3x +3₁

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Viewer cachePut cache://localLOAD_/static/knot_data/4z0q/A/4z0q_A.pdb.gz

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Help Knotting data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	+ 3₁	23-257	235	258-259	1-1	2-22	1	1	slipknot
view details	+ 3₁	25-234	210	1-24, 235-238			24	3	slipknot
view details	+ 3₁	24-232	209	1-23, 233-236			23	4	knot

	Fingerprint	Knot forming loop	Loop type
knots details	K +3₁	Chain closureHis3 <-> Lys261 ... His96 <-> Bridging ionZn1001 <-> His94 ... His3	probabilistic	color sequence
knots details	K +3₁	His3 ... His96 <-> Bridging ionZn1001 <-> His119 ... Chain closureLys261 <-> His3	probabilistic	color sequence
knots details	K +3₁	His3 ... His94 <-> Bridging ionZn1001 <-> His119 ... Chain closureLys261 <-> His3	probabilistic	color sequence

Chain Sequence

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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Help Knotoid subchains data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				3.1	27-257	231	1-26, 258-258			26	1	knot
view details				2.1	25-252	228	1-24	258-258	253-257	24	1	slipknot

sequence length	258
structure length	258
publication title	Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. pubmed doi rcsb
molecule tags	Lyase
molecule keywords	Carbonic anhydrase 2
source organism	Homo sapiens
total genus	Genus: 73
ec nomenclature	ec 4.2.1.1: Carbonic anhydrase.
pdb deposition date	2015-03-26
KnotProt deposition date	2018-10-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00194	Carb_anhydrase	Eukaryotic-type carbonic anhydrase

Image from the rcsb pdb (www.rcsb.org)

1AM6A 1AVNA 1BCDA 1BN1A 1BN3A 1BN4A 1BNMA 1BNNA 1BNQA
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1AM6 A; 1AVN A; 1BCD A; 1BN1 A; 1BN3 A; 1BN4 A; 1BNM A; 1BNN A; 1BNQ A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

4Z0QA

Slipknot S +31

Chain Sequence

Knot K 3x +31

Chain Sequence

pfam database annotations

Slipknot S +3₁

Knot K 3x +3₁