4ZG6A

Structural basis for inhibition of human autotaxin by four novel compounds
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-31 511-302 -208 1-510 643-804 303-642 510 162 slipknot
Chain Sequence
GSCKGRCFEL-------CRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIAALTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPFFQGDHG-----------FDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGTEERHLLYGRPAVLYRTR-------------------------YDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAK-------YDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 107-296 190 1-106 411-754 297-410 106 344 slipknot
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3.1 103-410 308 1-1, 413-754 2-102, 411-412 1 342 slipknot
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2.1m 493-574 82 1-492 585-754 575-584 492 170 slipknot
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3.1m 37-584 548 1-36 590-754 585-589 36 165 slipknot
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2.1m 492-584 93 1-491 595-754 585-594 491 160 slipknot
sequence length 804
structure length 754
publication title Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
source organism Homo sapiens
missing residues 11-17, 403-413, 511-535, 588-594
total genus Genus: 245
ec nomenclature
pdb deposition date 2015-04-22
KnotProt deposition date 2015-10-14
Image from the rcsb pdb (www.rcsb.org)
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