5FNM | KnotProt

Genus: 77
Alphaknot: P00918

Knot K +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	23-256	234	1-22, 257-259			22	3	knot

Chain Sequence

HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK

Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!

Knot K 3x +3₁

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Help Knotting data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Type
view details	+ 3₁	23-256	234	1-22, 257-259	22	3	knot
view details	+ 3₁	22-234	213	1-21, 235-238	21	4	knot
view details	+ 3₁	25-233	209	1-24, 234-236	24	3	knot

	Fingerprint	Knot forming loop	Loop type
knots details	K +3₁	Chain closureHis3 <-> Lys261 ... His96 <-> Bridging ionZn262 <-> His94 ... His3	probabilistic	color sequence
knots details	K +3₁	His3 ... His96 <-> Bridging ionZn262 <-> His119 ... Chain closureLys261 <-> His3	probabilistic	color sequence
knots details	K +3₁	His3 ... His94 <-> Bridging ionZn262 <-> His119 ... Chain closureLys261 <-> His3	probabilistic	color sequence

Chain Sequence

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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Help Knotoid subchains data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				3.1	25-257	233	1-24, 258-258			24	1	knot
view details				2.1	25-252	228	1-24	258-258	253-257	24	1	slipknot

sequence length	258
structure length	258
publication title	Native State Mass Spectrometry, Surface Plasmon Resonance and X-Ray Crystallography Correlate Strongly as a Fragment Screening Combination. pubmed doi rcsb
molecule tags	Lyase
molecule keywords	CARBONIC ANHYDRASE 2
source organism	Homo sapiens
total genus	Genus: 77
ec nomenclature
pdb deposition date	2015-11-15
KnotProt deposition date	2018-10-19

Image from the rcsb pdb (www.rcsb.org)

1CNWA 1CNXA 1CNYA 1EOUA 1G6VA 1HCAA 1KWQA 1KWRA 1T9NA
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1CNW A; 1CNX A; 1CNY A; 1EOU A; 1G6V A; 1HCA A; 1KWQ A; 1KWR A; 1T9N A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

5FNMA

Knot K +31

Chain Sequence

Knot K 3x +31

Chain Sequence

Knot K +3₁

Knot K 3x +3₁