5UGHA

Crystal structure of mat2a bound to the allosteric inhibitor pf-02929366
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 125
Alphaknot: P31153
Knot K +31 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 15-255 241 1-14, 256-384 14 129 knot
Chain Sequence
FIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQS-------------EDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPDAGLTGRKIIVDT--YGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 21-280 260 1-2, 360-384 3-20, 281-359 2 25 slipknot
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2.1 17-359 343 1-3, 364-384 4-16, 360-363 3 21 slipknot
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2.1 22-368 347 369-384 1-7 8-21 7 15 slipknot
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1.1 22-357 336 1-9, 369-384 10-21, 358-368 9 16 slipknot
sequence length 384
structure length 369
publication title Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-adenosylmethionine synthase isoform type-2
source organism Homo sapiens
missing residues 104-116, 245-246
total genus Genus: 125
ec nomenclature
pdb deposition date 2017-01-08
KnotProt deposition date 2018-09-13
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling