5DLVA

Crystal structure of autotaxin (enpp2) with tauroursodeoxycholic acid (tudca)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 116-301 186 1-115 432-804 302-431 115 373 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDV-------CFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDHTKGSTK----------------ERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCASSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 46-300 255 1-45 306-781 301-305 45 476 slipknot
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3.1 114-303 190 1-113 423-781 304-422 113 359 slipknot
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3.1 114-422 309 1-113 424-781 423-423 113 358 slipknot
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2.1 32-423 392 1-31 426-781 424-425 31 356 slipknot
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2.1 42-423 382 1-31, 426-781 32-41, 424-425 31 356 slipknot
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2.1 56-423 368 1-41, 426-781 42-55, 424-425 41 356 slipknot
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2.1 74-301 228 1-57, 304-781 58-73, 302-303 57 478 slipknot
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2.1 87-300 214 1-72, 304-781 73-86, 301-303 72 478 slipknot
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2.1 88-301 214 1-86, 304-781 87-87, 302-303 86 478 slipknot
sequence length 804
structure length 781
publication title Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
doi rcsb
molecule tags Hydrolase
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
source organism Rattus norvegicus
missing residues 406-412, 515-530
total genus Genus: 254
ec nomenclature
pdb deposition date 2015-09-07
KnotProt deposition date 2016-04-15
Image from the rcsb pdb (www.rcsb.org)
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