5EA4F

Crystal structure of inhibitor jnj-49153390 in complex with prefusion rsv f glycoprotein
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 140
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 28-267 240 1-27 273-481 268-272 27 209 slipknot
Chain Sequence
QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIK-----GTDAKVKLIKQELDKYKNAVTELQLLMQSTPATFLGFL---------------------------------LGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFI
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 32-262 231 1-31 276-481 263-275 31 206 slipknot
sequence length 481
structure length 443
publication title Molecular mechanism of respiratory syncytial virus fusion inhibitors.
pubmed doi rcsb
molecule tags Cell invasion/inhibitor
molecule keywords Fusion glycoprotein F0
source organism Human respiratory syncytial virus a (strain a2)
missing residues 41-45, 79-111
total genus Genus: 140
ec nomenclature
pdb deposition date 2015-10-15
KnotProt deposition date 2018-09-12
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling