5HYAA

Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchangerncx_mj soaked with 150 mm na+ and nominal ca2+
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 132
Knot K +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 39-229 191 1-38, 230-304 38 75 knot
Chain Sequence
MVILGVGYFLLGLILLYYGSDWFVLGSERIARHFNVSNFVIGATVMAIGTSLPEILTSAYASYMHAPGISIGNAIGSCICNIGLVLGLSAIISPIIVDKNLQKNILVYLLFVIFAAVIGIDGFSWIDGVVLLILFIIYLRWTVKNGSA-------KNNPSVVFSLVLLIIGLIGVLVGAELFVDGAKKIALALDISDKVIGFTLVAFGTSLPELMVSLAAAKRNLGGMVLGNVIGSNIADIGGALAVGSLFMHLPAENVQMAVLVIMSLLLYLFAKYSKIGRWQGILFLALYIIAIASLRMGGG
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 203x +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 41-229 189 1-40, 230-300 40 71 knot
Fingerprint Knot forming loop Loop type
K +31 Met1 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa401
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ser77 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Ser51 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77		 ion-based
K +31 Ala47 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ser77 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Met1 ... Glu54 <->
Bridging ionNa403
<-> Ala206 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Thr209 <->
Bridging ionNa403
<-> Ala206 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa401
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa403
<-> Ser77 ... Thr50		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa403
<-> Ser77 ... Ser51 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Glu54 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Glu54		 ion-based
K +31 Glu54 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Glu54		 ion-based
K +31 Met1 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ala206 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Met1		 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ser77 <->
Bridging ionNa403
<-> Ala206 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Met1 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ser51 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31 Ala47 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ala47		 ion-based
K +31 Thr50 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Thr50		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 ... Ser51 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Met1		 probabilistic
K +31 Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Ser51 <->
Bridging ionNa401
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Thr209 <->
Bridging ionNa403
<-> Ala206 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Glu54 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ala47		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa401
<-> Glu213 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Glu54 ... Ser51 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 ... Thr50 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ser51 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ser77 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Glu54 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31
Chain closureMet1 <-> Gly304
... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Met1		 probabilistic
K +31 Glu54 <->
Bridging ionNa402
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Glu54		 ion-based
K +31 Met1 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala206 ... Ser210 <->
Bridging ionNa403
<-> Ala206		 ion-based
K +31 Met1 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Glu213 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Glu54 ... Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Thr50		 ion-based
K +31 Thr50 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Met1 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Glu54 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ser77 <->
Bridging ionNa403
<-> Ala206 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Glu54 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Glu213 <->
Bridging ionNa401
<-> Thr50 ... Met1		 probabilistic
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Thr50		 ion-based
K +31 Thr50 ... Ser51 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Ser51 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Met1 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Met1 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa402
<-> Glu54		 ion-based
K +31 Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser77		 ion-based
K +31 Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Thr50 ... Met1		 probabilistic
K +31 Ser51 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ser51		 ion-based
K +31 Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31 Ala47 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Thr50 <->
Bridging ionNa401
<-> Ala47 ... Met1		 probabilistic
K +31 Ala47 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Met1		 probabilistic
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Thr50		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Met1 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Thr50 ... Ala47		 ion-based
K +31 Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Glu213 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Glu213 <->
Bridging ionNa401
<-> Ser51 ... Thr50		 ion-based
K +31 Thr50 ... Ser51 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 ... Ser51 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Ala47 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa403
<-> Ala206 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Met1		 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ser77 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Ser210 <->
Bridging ionNa403
<-> Ser77		 ion-based
K +31 Ser77 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77		 ion-based
K +31 Met1 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 ... Ser51 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Ser51 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ser51		 ion-based
K +31 Ser51 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser51 <->
Bridging ionNa401
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ala206		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Ala47 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 ... Ser77 <->
Bridging ionNa403
<-> Ala206 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Asp121 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ser51 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ser51		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Glu213 <->
Bridging ionNa401
<-> Thr50 ... Met1		 probabilistic
K +31 Ala47 ... Glu54 <->
Bridging ionNa403
<-> Ser77 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Gly122 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Met1		 probabilistic
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ser236 <->
Bridging ionNa401
<-> Ser51 ... Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Glu213 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Met1		 probabilistic
K +31 Ala47 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Ser236 <->
Bridging ionNa401
<-> Ala47		 ion-based
K +31 Ala47 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50 ... Ala47		 ion-based
K +31 Thr50 <->
Bridging ionNa401
<-> Ser236 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Thr209 <->
Bridging ionNa402
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Thr209 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp127 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31 Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu54		 ion-based
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Glu54 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ser51 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa403
<-> Ala206 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Ser51		 ion-based
K +31 Ser51 <->
Bridging ionNa401
<-> Glu213 ... Ser210 <->
Bridging ionNa403
<-> Ser77 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Thr209 <->
Bridging ionNa402
<-> Glu54 ... Ser51		 ion-based
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ... Thr209 <->
Bridging ionNa402
<-> Glu213 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Thr50 ... Ile118 <->
Bridging ionCa404
<-> Asp121 ... Ser236 <->
Bridging ionNa401
<-> Thr50		 ion-based
K +31
Chain closureMet1 <-> Gly304
... Ser236 <->
Bridging ionNa401
<-> Glu213 ... Thr209 <->
Bridging ionNa403
<-> Ala206 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Glu54 <->
Bridging ionNa402
<-> Thr50 ... Met1		 probabilistic
K +31 Met1 ... Glu54 <->
Bridging ionNa402
<-> Thr209 ... Asp121 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ... Glu213 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Glu54 <->
Bridging ionNa402
<-> Thr209 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser77 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Ala47 <->
Bridging ionNa401
<-> Ser51 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Ala206 <->
Bridging ionNa403
<-> Ser210 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Met1 ... Thr50 <->
Bridging ionNa402
<-> Thr209 ... Ser210 <->
Bridging ionNa403
<-> Ala206 ... Gly122 <->
Bridging ionCa404
<-> Ile118 ... Ser51 <->
Bridging ionNa401
<-> Ser236 ...
Chain closureGly304 <-> Met1
 probabilistic
K +31 Ser51 ... Ile118 <->
Bridging ionCa404
<-> Gly122 ... Glu213 <->
Bridging ionNa401
<-> Ser51		 ion-based
Chain Sequence
MVILGVGYFLLGLILLYYGSDWFVLGSERIARHFNVSNFVIGATVMAIGTSLPEILTSAYASYMHAPGISIGNAIGSCICNIGLVLGLSAIISPIIVDKNLQKNILVYLLFVIFAAVIGIDGFSWIDGVVLLILFIIYLRWTVKNGSA-------KNNPSVVFSLVLLIIGLIGVLVGAELFVDGAKKIALALDISDKVIGFTLVAFGTSLPELMVSLAAAKRNLGGMVLGNVIGSNIADIGGALAVGSLFMHLPAENVQMAVLVIMSLLLYLFAKYSKIGRWQGILFLALYIIAIASLRMGGG
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 20-248 229 1-19, 249-304 19 56 knot
view details
3.1 21-243 223 1-2, 261-304 3-20, 244-260 2 44 slipknot
view details
2.1 44-236 193 237-304 1-8 9-43 8 67 slipknot
view details
2.1 49-248 200 249-304 1-43 44-48 43 55 slipknot
view details
2.1 51-252 202 253-304 1-48 49-50 48 51 slipknot
view details
2.1 52-256 205 1-50, 299-304 51-51, 257-298 50 6 slipknot
sequence length 304
structure length 297
publication title Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords sodium,calcium exchanger
source organism Methanocaldococcus jannaschii (strain atcc 43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440)
missing residues 149-155
total genus Genus: 132
ec nomenclature
pdb deposition date 2016-02-01
KnotProt deposition date 2018-10-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.58.1130 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase; Chain G, domain 1 Methane Monooxygenase Hydroxylase; Chain G, domain 1 5hyaA01
1.20.1420.30 Mainly Alpha Up-down Bundle A middle domain of Talin 1 A middle domain of Talin 1 5hyaA02
5HYAA 5JDQA 5JDHA
chains in the KnotProt database with same CATH superfamily
5HYAA 5JDQA 5JDHA
chains in the KnotProt database with same CATH topology
5HYAA 5JDQA 5JDHA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 5HYA A;  5JDQ A;  5JDH A; 
#chains in the KnotProt database with same CATH topology
 5HYA A;  5JDQ A;  5JDH A; 
#chains in the KnotProt database with same CATH homology
 5HYA A;  5JDQ A;  5JDH A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling