5IEQA

Crystal structure of polymerase acid protein (pa) from influenza a virus, wilson-smith/1933 (h1n1) bound to fragment hit ebsi-747 1-(4-chlorophenyl)-1h-imidazole
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 19-287 269 1-11, 295-449 12-18, 288-294 11 155 slipknot
Chain Sequence
PRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGE--------------------------ELRSLASWIQNEFNKACELTDSSWIELDEIGEDAAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEVGDMLLRSAIGHVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSPKGVEEGSIGKVCRTLLAKSVFNSL--------YASPQLEGFSAESRKLLLIVQALRDNLGGLYEAIEECLINDPWVLLNASWFNSFLTH
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1m 23-280 258 1-11, 298-449 12-22, 281-297 11 152 slipknot
view details
2.1m 21-262 242 1-12, 274-449 13-20, 263-273 12 176 slipknot
sequence length 449
structure length 408
publication title Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
rcsb
molecule tags Viral protein
molecule keywords Polymerase acidic protein
source organism Influenza a virus (strain a/wilson-smith/1933 h1n1)
missing residues 109-134, 352-359, 413-419
total genus Genus: 139
ec nomenclature
pdb deposition date 2016-02-25
KnotProt deposition date 2018-09-16
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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