5IF7A

Crystal structure of polymerase acid protein (pa) from influenza a virus, wilson-smith/1933 (h1n1) bound to fragment hit ebsi-279 n-[(4-chlorophenyl)methyl]-1-methyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 136
Slipknot S -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-31 15-282 268 1-12, 288-447 13-14, 283-287 12 160 slipknot
Chain Sequence
PLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGE--------------------------ELRSLASWIQNEFNKACELTDSSWIELDEIGEDAAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEVGDMLLRSAIGHVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSPKGVEEGSIGKVCRTLLAKSVFNSL--------YASPQLEGFSAESRKLLLIVQALRDNLLGGLYEAIEECLINDPWVLLNASWFNSFLTH
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1m 20-278 259 1-9, 296-447 10-19, 279-295 9 152 slipknot
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2.1m 18-259 242 1-10, 272-447 11-17, 260-271 10 176 slipknot
sequence length 447
structure length 407
publication title Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
rcsb
molecule tags Viral protein
molecule keywords Polymerase acidic protein
source organism Influenza a virus (strain a/wilson-smith/1933 h1n1)
missing residues 107-132, 350-357, 411-416
total genus Genus: 136
ec nomenclature
pdb deposition date 2016-02-25
KnotProt deposition date 2018-09-16
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling