5IJSA

Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 245
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 116-301 186 1-115 432-804 302-431 115 373 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTK-FPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPC----------FFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCEEFNKRLHTKG----------STKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCASSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 41-299 259 1-40 307-783 300-306 40 477 slipknot
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3.1 114-302 189 1-113 418-783 303-417 113 366 slipknot
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3.1 114-417 304 1-113 419-783 418-418 113 365 slipknot
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3.1 114-418 305 1-113 420-783 419-419 113 364 slipknot
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2.1 61-299 239 1-41, 303-783 42-60, 300-302 41 481 slipknot
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2.1 70-299 230 1-60, 303-783 61-69, 300-302 60 481 slipknot
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2.1 73-299 227 1-69, 303-783 70-72, 300-302 69 481 slipknot
sequence length 804
structure length 783
publication title Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin
doi rcsb
molecule tags Hydrolase
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
source organism Rattus norvegicus
missing residues 154, 403-412, 514-523
total genus Genus: 245
ec nomenclature
pdb deposition date 2016-03-02
KnotProt deposition date 2016-06-16
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling