5KU6A

Crystal structure for the complex of human carbonic anhydrase iv and methazolamide
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 34-264 231 1-33, 265-266 33 2 knot
Chain Sequence
AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTS-------DPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 32-255 224 1-31, 256-259 31 4 knot
sequence length 266
structure length 259
publication title Characterization of recombinant human carbonic anhydrase IV thermal stability and intrinsic thermodynamics of inhibitor binding
rcsb
molecule tags Lyase/lyase inhibitor
molecule keywords Carbonic anhydrase 4
source organism Homo sapiens
missing residues 133-139
total genus Genus: 64
ec nomenclature
pdb deposition date 2016-07-12
KnotProt deposition date 2017-08-28
Image from the rcsb pdb (www.rcsb.org)
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