5KWWF

Crystal structure of inhibitor jnj-53718678 in complex with prefusion rsv f glycoprotein
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 132
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 29-263 235 1-28 272-480 264-271 28 209 slipknot
Chain Sequence
NITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIK--------AKVKLIKQELDKYKNAVTELQLLMQFLGFLLGV--------------------------------------GSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPISISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELL------SLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFI
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 32-209 178 1-31 223-428 210-222 31 206 slipknot
sequence length 480
structure length 428
publication title Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
pubmed doi rcsb
molecule tags Viral protein/inhibitor
molecule keywords Fusion glycoprotein F0, Envelope glycoprotein chimera
source organism Human respiratory syncytial virus
missing residues 40-47, 73-110, 181-186
total genus Genus: 132
ec nomenclature
pdb deposition date 2016-07-19
KnotProt deposition date 2017-08-28
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling