5MSBA

Crystal structure of human carbonic anhydrase isozyme xii with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-256 231 1-25, 257-261 25 5 knot
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 24-257 234 1-23, 258-261 23 4 knot
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2.1 14-254 241 1-13 259-261 255-258 13 3 slipknot
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3.1 26-258 233 259-261 1-23 24-25 23 2 slipknot
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2.1 24-255 232 1-14, 258-261 15-23, 256-257 14 4 slipknot
sequence length 261
structure length 261
publication title Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 12
source organism Homo sapiens
total genus Genus: 71
ec nomenclature
pdb deposition date 2017-01-02
KnotProt deposition date 2018-01-17
Image from the rcsb pdb (www.rcsb.org)
4KP5A 4KP8A 4Q0LA 4QJ0A 4QJOA 4QJWA 5LL5A 5LL9A 4WW8A
similar chains in the KnotProt database (40% sequence similarity)
None
similar chains in the pdb database (40% sequence similarity)

 
#similar chains in the KnotProt database (40% sequence similarity)
4KP5 A; 4KP8 A; 4Q0L A; 4QJ0 A; 4QJO A; 4QJW A; 5LL5 A; 5LL9 A; 
#similar chains, but unknotted
4WW8 A; 
#similar chains in the pdb database (40% sequence similarity)


KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling
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