5TCDA

Human alkaline sphingomyelinase (enpp7) in complex with phosphocholine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 133
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 9-217 209 1-8 336-388 218-335 8 53 slipknot
Chain Sequence
QNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTES
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 6-217 212 1-5 224-388 218-223 5 165 slipknot
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2.1 8-219 212 1-7 328-388 220-327 7 61 slipknot
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3.1 6-328 323 1-5 334-388 329-333 5 55 slipknot
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2.1 9-283 275 1-7, 293-388 8-8, 284-292 7 96 slipknot
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2.1 10-263 254 1-7, 272-388 8-9, 264-271 7 117 slipknot
sequence length 388
structure length 388
publication title Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
source organism Homo sapiens
total genus Genus: 133
ec nomenclature
pdb deposition date 2016-09-14
KnotProt deposition date 2017-03-26
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling