5XWKA

Crystal structure of spap, an alkaline phosphatase from sphingomonas in complex with inorganic phosphate
Genus: 191
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 19-315 297 1-18 472-530 316-471 18 59 slipknot
Chain Sequence
AARSIAATPPKLIVAISVDQFSADLFSEYRQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGHSTILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDESQPGSSSDKYEASPLHLKVPTLGGRMKAANPATRVVSVAGKDRAAIMMGGATADQVWWLGGPQGYVSYKGVAPTPLVTQVNQAFAQRLAQPNPGFELPAQCVSKDFPVQAGNRTVGTGRFARDAGDYKGFRISPEQDAMTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDRLDTELGAFFDKLDKDGIDYVVVLTADHGGHDLPERHRMNAMPMEQRVDMALTPKALNATIAEKAGLPGKKVIWSDGPSGDIYYDKGLTAAQRARVETEALKYLRAHPQVQTVFTKAEIAATPSPSGPPESWSLIQEARASFYPSRSGDLLLLLKPRVMSIPEQAVMGSVATHGSPWDTDRRVPILFWRKGMQHFEQPLGVETVDILPSLAALIKLPVPKDQIDGRCLDLVAGKDDSCAGQL
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 64x -31 2x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 22-120 99 1-21, 121-178 21 58 knot
Fingerprint Knot forming loop Loop type
K -31
Chain closureAla31 <-> Leu560
... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... His304 <->
Bridging ionZn603
<-> His491 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... His304 <->
Bridging ionZn603
<-> His491 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> His304 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> His304 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Gly551 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Gly551 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Gly551 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Gly551 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... His304 <->
Bridging ionZn603
<-> His491 ... Gly551 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... His304 <->
Bridging ionZn603
<-> His491 ... Gly551 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K +31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His304 <->
Bridging ionZn603
<-> Asp300 ... Cys126 <-> Cys90 ... Ala31		 probabilistic
K +31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... Cys314 <-> Cys231 ... Cys126 <-> Cys90 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Cys556 <-> Cys545 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Val549 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Gly551 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Val549 <->
Bridging ionCa604
<-> Gly551 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Val549 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Gly551 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Gly551 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> His346 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Gly551 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31 Ala31 ... Thr89 <->
Bridging ionZn602
<-> Asp345 ... Cys314 <-> Cys231 ... His304 <->
Bridging ionZn603
<-> His491 ... Gly551 <->
Bridging ionCa604
<-> Asp553 ...
Chain closureLeu560 <-> Ala31
 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Asp553 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> Asp300 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... His346 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
K -31
Chain closureAla31 <-> Leu560
... Gly551 <->
Bridging ionCa604
<-> Asp547 ... His491 <->
Bridging ionZn603
<-> His304 ... Cys231 <-> Cys314 ... Asp345 <->
Bridging ionZn602
<-> Thr89 ... Ala31		 probabilistic
Chain Sequence
AARSIAATPPKLIVAISVDQFSADLFSEYRQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGHSTILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDESQPGSSSDKYEASPLHLKVPTLGGRMKAANPATRVVSVAGKDRAAIMMGGATADQVWWLGGPQGYVSYKGVAPTPLVTQVNQAFAQRLAQPNPGFELPAQCVSKDFPVQAGNRTVGTGRFARDAGDYKGFRISPEQDAMTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDRLDTELGAFFDKLDKDGIDYVVVLTADHGGHDLPERHRMNAMPMEQRVDMALTPKALNATIAEKAGLPGKKVIWSDGPSGDIYYDKGLTAAQRARVETEALKYLRAHPQVQTVFTKAEIAATPSPSGPPESWSLIQEARASFYPSRSGDLLLLLKPRVMSIPEQAVMGSVATHGSPWDTDRRVPILFWRKGMQHFEQPLGVETVDILPSLAALIKLPVPKDQIDGRCLDLVAGKDDSCAGQL
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 11-314 304 1-10 320-530 315-319 10 211 slipknot
view details
3.1 17-317 301 1-16 470-530 318-469 16 61 slipknot
view details
2.1 10-469 460 1-9 473-530 470-472 9 58 slipknot
view details
2.1 9-472 464 1-8 474-530 473-473 8 57 slipknot
sequence length 530
structure length 530
publication title Crystal Structure of SPAP, an alkaline phosphatase from Sphingomonas in complex with
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase PhoK
source organism Sphingomonas sp.
total genus Genus: 191
ec nomenclature
pdb deposition date 2017-06-29
KnotProt deposition date 2018-09-26
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling