6B5A | KnotProt

Genus: 76
Alphaknot: P00918

Slipknot S +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	22-254	233	255-258	1-1	2-21	1	3	slipknot

Chain Sequence

HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK

Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!

Knot K 3x +3₁

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Jmol getValue APPLETREADYCallback Jmol._readyCallback

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Help Knotting data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	+ 3₁	24-255	232	256-258	1-1	2-23	1	2	slipknot
view details	+ 3₁	24-234	211	1-23, 235-237			23	3	knot
view details	+ 3₁	23-231	209	1-22, 232-235			22	4	knot

	Fingerprint	Knot forming loop	Loop type
knots details	K +3₁	His4 ... His94 <-> Bridging ionZn301 <-> His96 ... Chain closureLys261 <-> His4	probabilistic	color sequence
knots details	K +3₁	His4 ... His96 <-> Bridging ionZn301 <-> His119 ... Chain closureLys261 <-> His4	probabilistic	color sequence
knots details	K +3₁	His4 ... His94 <-> Bridging ionZn301 <-> His119 ... Chain closureLys261 <-> His4	probabilistic	color sequence

Chain Sequence

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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APPLETREADYCallback = "Jmol._readyCallback"

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Help Knotoid subchains data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				3.1	26-256	231	1-25, 257-257			25	1	knot
view details				2.1	24-251	228	1-23	257-257	252-256	23	1	slipknot

sequence length	257
structure length	257
publication title	Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. pubmed doi rcsb
molecule tags	Lyase/inhibitor
molecule keywords	Carbonic anhydrase 2
source organism	Homo sapiens
total genus	Genus: 76
ec nomenclature
pdb deposition date	2017-09-28
KnotProt deposition date	2018-10-20

Image from the rcsb pdb (www.rcsb.org)

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similar chains in the KnotProt database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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6B5AA

Slipknot S +31

Chain Sequence

Knot K 3x +31

Chain Sequence

Slipknot S +3₁

Knot K 3x +3₁