6FF4y

Human bact spliceosome core structure
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 19-67 49 1-18, 68-100 18 33 knot
Chain Sequence
AKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYE
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 17x -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 10-58 49 1-9, 59-76 9 18 knot
Fingerprint Knot forming loop Loop type
K -31 Cys11 ... Cys85 <->
Bridging ionZn201
<-> Cys11
ion-based
K -31 Cys11 <->
Bridging ionZn201
<-> Cys85 ... Cys26 <->
Bridging ionZn202
<-> Cys23 ... Cys11
ion-based
K -31 Cys11 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ... Cys85 <->
Bridging ionZn201
<-> Cys11
ion-based
K -31 Cys11 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ... Cys85 <->
Bridging ionZn201
<-> Cys11
ion-based
K -31 Ala2 ... Cys46 <->
Bridging ionZn201
<-> Cys49 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31
Chain closureAla2 <-> Glu101
... Cys26 <->
Bridging ionZn202
<-> Cys23 ... Ala2
probabilistic
K -31 Ala2 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Cys11 <->
Bridging ionZn201
<-> Cys85 ... Cys75 <->
Bridging ionZn203
<-> Cys72 ... Cys26 <->
Bridging ionZn202
<-> Cys23 ... Cys11
ion-based
K -31 Cys11 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ... Cys85 <->
Bridging ionZn201
<-> Cys11
ion-based
K -31
Chain closureAla2 <-> Glu101
... Cys49 <->
Bridging ionZn201
<-> Cys46 ... Cys26 <->
Bridging ionZn202
<-> Cys23 ... Ala2
probabilistic
K -31 Ala2 ... Cys46 <->
Bridging ionZn201
<-> Cys49 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys46 <->
Bridging ionZn201
<-> Cys49 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys23 <->
Bridging ionZn202
<-> Cys26 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys23 <->
Bridging ionZn202
<-> Cys26 ... Cys46 <->
Bridging ionZn201
<-> Cys49 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
K -31 Ala2 ... Cys46 <->
Bridging ionZn201
<-> Cys49 ... Cys58 <->
Bridging ionZn202
<-> Cys61 ... Cys72 <->
Bridging ionZn203
<-> Cys75 ...
Chain closureGlu101 <-> Ala2
probabilistic
Chain Sequence
AKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1m 19-86 68 1-18, 87-100 18 14 knot
view details
3.1m 17-69 53 1-16 87-100 70-86 16 14 slipknot
sequence length 100
structure length 100
publication title Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
pubmed doi rcsb
molecule tags Splicing
molecule keywords RNA-binding motif protein, X-linked 2
total genus Genus: 15
ec nomenclature
pdb deposition date 2018-01-03
KnotProt deposition date 2018-10-18
Image from the rcsb pdb (www.rcsb.org)
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