6G5LA

Crystal structure of human carbonic anhydrase isozyme xii with 4-chloro-2-(cyclohexylamino)-n-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Genus: 72
Alphaknot: O43570
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 24-257 234 1-23, 258-261 23 4 knot
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-234 211 1-23, 235-239 23 5 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His93 ... Lys3		 probabilistic
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His91 ... Lys3		 probabilistic
K +31
Chain closureLys3 <-> Gln263
... His93 <->
Bridging ionZn301
<-> His91 ... Lys3		 probabilistic
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 25-259 235 1-24, 260-261 24 2 knot
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2.1 26-254 229 1-25 260-261 255-259 25 2 slipknot
sequence length 261
structure length 261
publication title Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 12
source organism Homo sapiens
total genus Genus: 72
ec nomenclature
pdb deposition date 2018-03-29
KnotProt deposition date 2019-03-20
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling