6GDCA

Human carbonic anhydrase ii in complex with benzenesulfonamide
Genus: 74
Alphaknot: P00918
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-255 232 1-23, 256-258 23 3 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 15x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 22-254 233 1-21, 255-258 21 4 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo303
<-> Gln137 ... His4		 probabilistic
K +31 His4 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
 probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
 probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo303
<-> Gln137 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo303
<-> Gln137 ... His96 <->
Bridging ionZn301
<-> His94 ... His4		 probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo303
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His96 ... His4		 probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo303
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His94 ... His4		 probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo303
<-> Gln137 ... His96 <->
Bridging ionZn301
<-> His94 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo303
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His96 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo303
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His94 ... His4		 probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-255 230 1-25, 256-257 25 2 knot
view details
2.1 24-251 228 1-23 257-257 252-256 23 1 slipknot
sequence length 257
structure length 257
publication title Human Carbonic Anhydrase II in complex with Benzenesulfonamide
rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
total genus Genus: 74
ec nomenclature
pdb deposition date 2018-04-23
KnotProt deposition date 2019-05-10
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling