6ACGA

Trypsin-cleaved and low ph-treated sars-cov spike glycoprotein and ace2 complex, ace2-bound conformation 1
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 181
Slipknot S +31 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 596-1018 423 1-10, 1029-1102 11-595, 1019-1028 10 74 slipknot
Chain Sequence
RCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTINHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAILTAFS----IWGTSAAAYFVGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYIVAY-------------TMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLAICAQKFNGLTVLPPLLT--------------------DDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTV
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.10m 19-1017 999 1-18 1025-1102 1018-1024 18 78 slipknot
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2.1 320-1022 703 1-21, 1031-1102 22-319, 1023-1030 21 72 slipknot
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2.1 320-1030 711 1-22, 1032-1102 23-319, 1031-1031 22 71 slipknot
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4.10m 319-1017 699 1-22, 1023-1102 23-318, 1018-1022 22 80 slipknot
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2.1 423-1023 601 1-319, 1032-1102 320-422, 1024-1031 319 71 slipknot
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4.10m 388-1017 630 1-318, 1024-1102 319-387, 1018-1023 318 79 slipknot
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2.1 684-1022 339 1-387, 1031-1102 388-683, 1023-1030 387 72 slipknot
sequence length 1102
structure length 1065
publication title Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2.
pubmed doi rcsb
molecule tags Viral protein/hydrolase
molecule keywords Spike glycoprotein
source organism Human sars coronavirus
missing residues 223-226, 644-656, 795-814
total genus Genus: 181
ec nomenclature
pdb deposition date 2018-07-26
KnotProt deposition date 2018-09-14
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling