6EAGF

Crystal structure of fusion inhibitor jnj-2408068 in complex with human respiratory syncytial virus fusion glycoprotein escape variant g143s stabilized in the prefusion state
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 118
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-264 239 1-25 272-485 265-271 25 214 slipknot
Chain Sequence
NITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIK---------KVKLIKQELDKYKNAVTELQLLMQFLGFLLSVG--------------------------------------SAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDM------------PITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 29-266 238 1-28 270-485 267-269 28 216 slipknot
sequence length 485
structure length 426
publication title Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
rcsb
molecule tags Viral protein
molecule keywords Fusion glycoprotein F0
source organism Human respiratory syncytial virus
missing residues 40-48, 73-110, 180-191
total genus Genus: 118
ec nomenclature
pdb deposition date 2018-08-03
KnotProt deposition date 2019-09-06
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling