6EAKF

Crystal structure of fusion inhibitor jnj-2408068 in complex with human respiratory syncytial virus fusion glycoprotein escape variant t400a stabilized in the prefusion state
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 139
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 28-264 237 1-27 271-480 265-270 27 210 slipknot
Chain Sequence
NITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNI------GTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRAFLGFLL-----------------------------GVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVS-------TYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKADVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFI
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 24-267 244 1-23 270-480 268-269 23 211 slipknot
sequence length 480
structure length 438
publication title Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
rcsb
molecule tags Viral protein
molecule keywords Fusion glycoprotein F0
source organism Human respiratory syncytial virus
missing residues 39-44, 82-110, 181-187
total genus Genus: 139
ec nomenclature
pdb deposition date 2018-08-03
KnotProt deposition date 2019-09-06
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling