6EN4D

Sf3b core in complex with a splicing modulator
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 16-63 48 1-15, 64-93 15 30 knot
Chain Sequence
PDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDL
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 17x -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
- 31 11-58 48 1-10, 59-76 10 18 knot
Fingerprint Knot forming loop Loop type
K -31 Cys11 ... Cys85 <->
Bridging ionZn103
<-> Cys11
ion-based
K -31 Cys11 ... Cys72 <->
Bridging ionZn101
<-> Cys75 ... Cys85 <->
Bridging ionZn103
<-> Cys11
ion-based
K -31 Cys11 ... Cys30 <->
Bridging ionZn101
<-> Cys33 ... Cys85 <->
Bridging ionZn103
<-> Cys11
ion-based
K -31 Cys11 <->
Bridging ionZn103
<-> Cys85 ... Cys61 <->
Bridging ionZn102
<-> Cys58 ... Cys11
ion-based
K -31 Pro6 ... Cys72 <->
Bridging ionZn101
<-> Cys75 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys30 <->
Bridging ionZn101
<-> Cys33 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Cys11 <->
Bridging ionZn103
<-> Cys85 ... Cys75 <->
Bridging ionZn101
<-> Cys72 ... Cys61 <->
Bridging ionZn102
<-> Cys58 ... Cys11
ion-based
K -31 Cys11 <->
Bridging ionZn103
<-> Cys85 ... Cys61 <->
Bridging ionZn102
<-> Cys58 ... Cys33 <->
Bridging ionZn101
<-> Cys30 ... Cys11
ion-based
K -31 Pro6 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ... Cys72 <->
Bridging ionZn101
<-> Cys75 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys30 <->
Bridging ionZn101
<-> Cys33 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ... Cys72 <->
Bridging ionZn101
<-> Cys75 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys30 <->
Bridging ionZn101
<-> Cys33 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ... Cys72 <->
Bridging ionZn101
<-> Cys75 ...
Chain closureLeu98 <-> Pro6
probabilistic
K -31 Pro6 ... Cys30 <->
Bridging ionZn101
<-> Cys33 ... Cys46 <->
Bridging ionZn103
<-> Cys49 ... Cys58 <->
Bridging ionZn102
<-> Cys61 ...
Chain closureLeu98 <-> Pro6
probabilistic
Chain Sequence
PDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1m 15-87 73 1-14, 88-93 14 6 knot
view details
3.1m 14-65 52 1-13 88-93 66-87 13 6 slipknot
sequence length 93
structure length 93
publication title Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
pubmed doi rcsb
molecule tags Splicing
molecule keywords Splicing factor 3B subunit 3
source organism Homo sapiens
total genus Genus: 16
ec nomenclature
pdb deposition date 2017-10-04
KnotProt deposition date 2018-10-17
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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