6FE1A

Three dimensional structure of human carbonic anhydrase ix in complex with benzenesulfonamide.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 19-255 237 1-18, 256-257 18 2 knot
Chain Sequence
WRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 19-254 236 1-18, 255-257 18 3 knot
Fingerprint Knot forming loop Loop type
K +31 Trp5 ... His94 <->
Bridging ionZn301
<-> His96 ... Pro261 <-> Trp5
probabilistic
K +31 Trp5 ... His96 <->
Bridging ionZn301
<-> His119 ... Pro261 <-> Trp5
probabilistic
K +31 Trp5 ... His94 <->
Bridging ionZn301
<-> His119 ... Pro261 <-> Trp5
probabilistic
Chain Sequence
WRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 20-250 231 1-19, 251-251 19 1 knot
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2.1 20-245 226 1-19 251-251 246-250 19 1 slipknot
publication title Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.
pubmed doi rcsb
structure length 251
molecule tags Lyase
source organism Homo sapiens
sequence length 251
total genus Genus: 70
molecule keywords Carbonic anhydrase 9
ec nomenclature
pdb deposition date 2017-12-28
KnotProt deposition date 2018-10-19
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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