6G7AA

Crystal structure of human carbonic anhydrase isozyme xii 2-(benzylamino)-4-chloro-n-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Genus: 76
Alphaknot: O43570
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 25-257 233 1-24, 258-262 24 4 slipknot
Chain Sequence
SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 28-236 209 1-27, 237-240 27 4 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureSer2 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His93 ... Ser2		 probabilistic
K +31
Chain closureSer2 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His91 ... Ser2		 probabilistic
K +31
Chain closureSer2 <-> Gln263
... His93 <->
Bridging ionZn301
<-> His91 ... Ser2		 probabilistic
Chain Sequence
SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 27-260 234 1-26, 261-262 26 2 knot
view details
2.1 26-255 230 1-25 261-262 256-260 25 2 slipknot
sequence length 262
structure length 262
publication title Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 12
source organism Homo sapiens
total genus Genus: 76
ec nomenclature
pdb deposition date 2018-04-05
KnotProt deposition date 2019-03-20
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling