6G9UA

Three dimensional structure of human carbonic anhydrase ix in complex with sulfonamide
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 6-242 237 243-244 1-1 2-5 1 1 slipknot
Chain Sequence
RVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 8-242 235 1-7, 243-244 7 2 knot
Fingerprint Knot forming loop Loop type
K +31 Arg18 <-> Pro261 ... His96 <->
Bridging ionZn301
<-> His94 ... Arg18
probabilistic
K +31 Arg18 <-> Pro261 ... His119 <->
Bridging ionZn301
<-> His96 ... Arg18
probabilistic
K +31 Arg18 <-> Pro261 ... His119 <->
Bridging ionZn301
<-> His94 ... Arg18
probabilistic
Chain Sequence
RVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 11-238 228 1-10, 239-241 10 3 knot
view details
2.1 9-236 228 1-8 240-241 237-239 8 2 slipknot
publication title Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.
pubmed doi rcsb
structure length 241
molecule tags Lyase
source organism Homo sapiens
sequence length 241
total genus Genus: 66
molecule keywords Carbonic anhydrase 9
ec nomenclature
pdb deposition date 2018-04-11
KnotProt deposition date 2018-10-18
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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