6H36A

The crystal structure of human carbonic anhydrase vii in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-255 232 1-23, 256-259 23 4 knot
Chain Sequence
GWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKSLLPASRHYWTYPGSLTTPPLSESVTWIVLREPISISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 4x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-255 232 1-23, 256-259 23 4 knot
Fingerprint Knot forming loop Loop type
K +31 Gly4 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureAla262 <-> Gly4
probabilistic
K +31 Gly4 ... Cys54 <-> Cys178 ...
Chain closureAla262 <-> Gly4
probabilistic
K +31 Gly4 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureAla262 <-> Gly4
probabilistic
K +31 Gly4 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureAla262 <-> Gly4
probabilistic
Chain Sequence
GWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKSLLPASRHYWTYPGSLTTPPLSESVTWIVLREPISISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-256 231 1-25, 257-259 25 3 knot
view details
2.1 24-252 229 1-23 257-259 253-256 23 3 slipknot
sequence length 259
structure length 259
publication title Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 7
source organism Homo sapiens
total genus Genus: 79
ec nomenclature
pdb deposition date 2018-07-17
KnotProt deposition date 2019-01-08
Image from the rcsb pdb (www.rcsb.org)
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